KMID : 0361720050160010008
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Korean Journal of perinatology 2005 Volume.16 No. 1 p.8 ~ p.14
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Cytogenetic Analysis in Spontaneous Abortion.
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Ko Hyun-Sun
Kim Yeon-Hee Ahn Hyun-Young Park In-Yang Lee Young Kim Sa-Jin Rha Jong-Gu Shin Jong-Chul
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Abstract
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Object: To analyze the frequency and the types of chromosomal abnormalities in conceptus of spontaneous abortion
Object: 81 cases of products of conception aborted spontaneously were collected From Nov. 1999 to May, 2004 in the cytogenetic laboratory at Kangnam St. Mary¡¯s Hospital, Catholic University Medical College. The cytogenetic results,along with clinical information including gestational age at the time of the miscarriage and maternal age, were compiled in a database.
Results: Cytogenetic results were obtained from 76 cases (93.8%), of which 33 cases (43.4%) showed chromosome abnormalities. Of 33 chromosomal abnormalities, 12 cases (36.4%) showed monosomy X, including one case of 46,X,+7 and the other case of 44,X, t(13q14q). Autosomal trisomy was also detected in 12 cases (36.4%). The most frequent autosomal trisomy was that of chromosome 18 (4 cases), which occurred exclusively in old maternal age (37.8+/-7.5 years old). Mosaicism was found in 2 cases. Triploidy was identified in 4 cases. Structural abnormalities were identified in 3 cases.
Conclusion: This study showed that monosomy X and trisomy were the most common chromosomal abnormalities in spontaneous abortion, and autosomal trisomy was dependant on maternal age.
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KEYWORD
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Spontaneous avortion, Chromosome abnormality
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